Christina Applegate Opens Up About ‘Married… with Children,’ Her MS Diagnosis, and More

Actress Christina Applegate opens up about acting in “Married… with Children,” talks about the moon necklace Stevie Nicks gave her, reflects on her doctor telling she had 30 lesions on her brain from multiple sclerosis, and much more during a new episode of SiriusXM’s exclusive show “This Life of Mine with James Corden.”

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“They did an MRI in my brain,” Christina recalls, “and it was a Monday, and we were at work. And my doctor said, ‘I really need to get on a Zoom with you to go over your MRI results.’ And I opened up my Zoom and there he was, and he just looked at me and he goes, ‘I’m so sorry.’ And I was like, ‘What do you mean?’ And he goes, ‘Here’s a picture of your brain, sorry.’ And there’s like 30 lesions all over my brain. And I went, ‘No, please don’t tell me this. Please don’t.’”

Featuring in-depth, richly produced conversations between James Corden and a variety of prominent guests on the people, places, possessions, music, and memories that made them, “This Life of Mine with James Corden” tells the never-before-heard stories that shaped the people at the top of their field across film and television, sports, fashion, music, theater, business, and more.

(Photo by Emma McIntyre/Getty Images for SiriusXM)

New episodes air Thursdays at 5pm ET on Stars (Ch. 109). Stream episodes anytime after their premiere on the SiriusXM app.

Previous guests on “This Life of Mine with James Corden” include Tom Ford, Martin Scorsese, Kim Kardashian, Odell Beckham Jr., Jeremy Renner, Dr. Dre, David Beckham, Billy Porter, Anna Wintour, Brandi Carlile, and more.